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@brightlight66 I'm 72, stage 1a & starting with half-dose (10 mg) of Tamoxifen tonight! (Weak bones, couldn't do the AI's). My oncologist actually prescribed the low dose, somewhat reluctantly. I'm hoping I do ok! Fingers crossed & Happy 2026 to us all!

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Replies to "@brightlight66 I'm 72, stage 1a & starting with half-dose (10 mg) of Tamoxifen tonight! (Weak bones,..."

@jmab Best wishes to you jmab! I'm glad you're doing the low dose. I hope you don't have any side effects at all. I just read about Exemestane taken 3X/week had a non-inferior effect and intermittent dosing of Letrozole too. Of course the studies are not funded by the drug companies. So here we are...pioneers marching forward doing our best. I've attached what I found here:

Reduced dosing schedules have been explored as a way to potentially manage side effects, which are a common reason patients may discontinue their medication.
One study found that taking the AI exemestane on a schedule approximately every other day was comparable to a once-daily dose in suppressing estrogen levels in compliant participants. This research suggests that a less frequent schedule might maintain effectiveness while potentially being easier for patients to tolerate.
Another study investigating intermittent dosing of letrozole also indicated notable estrogen suppression, potentially offering benefits for patients' quality of life and adherence to treatment.