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Anyone had success with gemcitabine and capecitabine (GemCap) chemo?

Pancreatic Cancer | Last Active: Dec 31, 2025 | Replies (8)
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@val64
Thank you for your response. The following is from my test results:
"This individual has reduced DPD activity (activity score of
1.5) due to a heterozygous variant with reduced activity.
Based on this activity score, this individual is expected
to be an intermediate metabolizer and may be at increased
risk for severe or fatal drug toxicity when treated with
fluoropyrimidines at a standard dose."
I don't see any mention of 1 bad copy or 1 good copy, so I'm clueless here...
The test results came in Dec 21st but I haven't heard from my oncologist regarding changes to the proposed GemCap treatment but I'm sure the holidays have gotten in the way...

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Replies to "@val64 Thank you for your response. The following is from my test results: "This individual has..."
val64 | @val64 | Dec 31, 2025

@reme51

"Heterozygous" is genetics-speak for one good copy of a gene and one bad (aka mutated) copy. (You have two copies of most genes, one inherited from each parent.) You probably have the same type of mutated DPYD gene as me, since mine also has reduced activity (but not zero activity), and it is the most common mutated version of the gene, being found in ~5% of people of European background, and slightly less frequently in other populations.

Hope you get more clarity from your oncologist after the holidays. Don't freak out over the scary test report comment. Happy New Year.

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