@helen1000 As far as I know, a few people may have genetic markers that predispose them to Bronchiectasis, but largely it is not considered a genetic disease at this point. Of course, someday, with further research and more gene sequencing, that could change.
My BE is thought to be the result of years of undertreated asthma, repeated lung infections, and possibly early e posture to a number of irritants. Someone else in my family as rheumatoid arthritis that is thought to be the cause of their BE. In some people it is considered idiopathic, meaning cause unknown.

As for the one vial of saline versus two, what does the doctor say? I would be surprised if they didn't consider that as a possible cause of your hemoptysis, do they know how much you are using?

Also, if you don't bring up much mucus, exercise might help without irritating your lungs. I do yoga or brisk walking to get my lungs working, and what little mucus I have just comes up. Since I have no NTM and am prone to hoarseness and vocal chord dysfunction, I only use saline occasionally (but use my inhaler daily) before clearance. My pulmonologists agree with this protocol, unless I have a cold or other respiratory issues.