To distill what Jeff wrote, prostate cancer can be "castrate-sensitive" or "castrate-resistant."

If it responds to hormone therapy (ADT) like Lupron, then it's classified as castrate-sensitive.

If it does not respond to hormone therapy, then it's classified as castrate-resistant.

Sometimes metastatic (incurable) prostate cancer like mine starts out as castrate-sensitive, but then becomes castrate-resistant after a few years.

Oncologists used to assume that transition would *always* happen for metastatic prostate cancer within a couple of years, but researchers have recently discovered that newer drugs like the -lutamides, if started at the same time as an ADT like Lupron or Orgovyx, can delay or even prevent the transition to castrate-resistance indefinitely in many cases. My cancer is still castrate-sensitive after 4 years, 3 months on ADT + Apalutamide.

There are excellent treatments available for both situations, but they're somewhat different, which is why it's important for your husband's oncology team to determine which classification currently applies to the OP's husband's cancer