Were they one month shots or three month shots?

When my PSA started rising while I was on ADT, they told me I was castrate resistant and put me on Zytiga, which brought my PSA back down. That was after being on ADT for 2 1/2 years, however. That would be unusual when Lupron is first started, but it does happen.

If they didn’t give him Casodex (Biclutamide) For at least two weeks before Lupron, then it can cause a testosterone rise and a PSA rise. The thing is that only lasts for about three weeks and then the testosterone goes back down and the PSA should also.

Has he had a biopsy? What was the Gleason score? Has he had a PSMA PET scan? If it’s a high Gleason score and the scan showed metastasis outside the prostate then the PSA Can continue rising, even with Lupron.

The doctor may want to put him on an ARPI like Zytiga, apalutamide, Enzalutamide or Darolutamide Which can usually keep the PSA down for a significant amount of time.