@dido2 Hi. My Hashimoto’s thyroid disease is treated with Synthroid and is stable.
For the ME/CFS, I’ve tried so many different treatments over 40 years that O honestly can’t remember them all.
They included various kinds of diets and many different vitamins and supplements.
Prescription wise, to begin I was on gamma globulin shots for the first two years. I have no way of knowing if they were helping by preventing me to get worse (I was almost completely bedridden the first 3 years).
B12-shots, antidepressants, antivirals (Valcyclovir and Famcyclovir for 3 years- which only made me more fatigued.

Aside from my current thyroid meds, Estradiol, a beta blocker I take for my heart, and Nexium for GERD, the only medication that has truly made a difference is low dose Naltrexone. I’ve been on it 10 years primarily for pain caused by arthritis, fibromyalgia, Me/CFS (muscle aches) and severe Polyneuropathy. I have never had to take anything stronger than an occasional Alieve - which is highly unusual given all my pain issues.

Other than that nothing has ever helped much. I am 100% disabled due to ME/CFS and neuropathy and spend most of the day lying down. I can only stand for about 20 minutes at a time. I must add that over the years I had improved to abt 70% and could travel and enjoy life much more. But this disease waxes and wanes and old age hasn’t helped any, that’s for sure.