I experienced blurry vision with 5FU Chemo as well. You can get some thick eye drops, ones that keep the eye moistened longer, that seems to help. Warning, when you first put in the thick eyedrops, your vision is actually worse for a about 10 minutes. You can also get gel eye compresses that you can keep in the freezer or fridge. It helps to put these on the eyes once every hour or so, if you are working on the computer. This helps to refresh things a bit. Some medicines also mess with vision. Gabapentin also blurs the vision, so I asked to be put on oxycontin instead, even though this made me itchy. I took this with an antihistamine to help with this. Everyone is so different, and the medicines prescribed are different. Work with your doctor to find a solution. I don't know about the muscle twitches, but maybe your doctor has a solution. Best of luck to you. You are tougher than you think.