@dadcue I started on actemra about 2 months after starting on prednisone. my rheumatologist is very high on actemra versus prednisone. Being that I was basically on both of them simultaneously and then had some mini flares once I was off prednisone for about a month and a half to two months, I feel that the actemra works very well at cutting down the amount of prednisone you have to take fairly early in your treatment of PMR, but I think, from my own experience, that you still may need the combo, but with prednisone in a much lower dose for a while. Until I am off of everything but the actemra for a period of time, I won’t be able to make a solid judgment. I do think that the infusions of actemra with a low dose of prednisone, in my own experience of being treated for 11 months, and hopefully on actema only, very shortly, seems to be the way to go. I’ll keep you posted!!! until I had discovered this “Mayo Clinic Connect”, I felt as though I was living in the “ Twilight Zone” with my vague and mysterious symptoms.