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@lorry I haven’t seen any recommendations to take B6 unless you have a deficiency. I always discuss supplements with my doctor before taking them. Do you have a link to the Mayo resource where you read B6 is recommended?

I do think that you shouldn’t take B6 if you already have neuropathy unless you have a deficiency.

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@johnbishop I started a thread about this almost a year ago when I was diagnosed with B6 toxicity (taking 25mg in a magnesium supplement). I had my 12 month blood test a few weeks ago and the woman who took my blood noticed the ‘history of B6 toxicity’ on the form. She exclaimed “you too?!” And went on to explain that after many years of collecting blood for testing, in the past year she had seen what could only be described as an epidemic. Once the problem started to appear on news programs, people got tested and an alarming number had very high readings.
Because toxicity symptoms mimic deficiency symptoms, some people were even being prescribed supplements.
With new laws coming in here, I thought I’d google and see if other countries were doing the same thing.
I was astonished to see a Mayo clinic update August 2025 with ‘safe’ and a green light!
http://www.mayoclinic.org/drugs-supplements-vitamin-b6/art-20363468