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Anyone successfully treating PMR without Prednisone?
Polymyalgia Rheumatica (PMR) | Last Active: 1 day ago | Replies (38)Comment receiving replies
I had to stop Prednisone and anti-inflamnatories about a year ago due to other medical reasons. Started on anti-inflamnatory diet fron Harvard, helped a lot. Took a lot of supplements, but only now discovered a drug that really makes a difference: Dapagliflozin (Forxiga). I take metformin for prediabetes, 1g twice daily. Read about Forxiga on Medscape, I now take 5mg at night, makes a huge difference. Reduced Metformin dose to 500mg twice a day. I also take Tylenol arthritis 1 at night.
Combination is helping a lot.
Impact of SGLT2 Inhibitors and GLP-1 Agonists on RA Flares
in Patients on DMARD Therapy: A Retrospective Study
https://acrabstracts.org/abstract/impact-of-sglt2-inhibitors-and-glp-1-agonists-on-ra-flares-in-patients-on-dmard-therapy-a-retrospective-study/
Replies to "I had to stop Prednisone and anti-inflamnatories about a year ago due to other medical reasons...."
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@martha13
Forxiga (dapagliflozin) is a first-in-class SGLT2 inhibitor, a type of oral medication that helps the kidneys remove excess sugar from the body. I can see how it would help control inflammation.
I'm on Wegovy (semaglutide) a GLP-1 receptor agonist to treat my weight gain caused by Prednisone. I lost 30 pounds on Wegovy. Now my endocrinologist is considering Zepbound to see if it would offer some additional benefits.
https://www.everydayhealth.com/obesity/zepbound-vs-wegovy-which-treatment-is-right-for-you/
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I have metabolic dysfunction from long term prednisone use.
https://www.everydayhealth.com/liver-disease/nonalcoholic-fatty-liver-disease/
and
https://www.healthline.com/health/prednisone-and-fatty-liver-disease
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I took Prednisone for 12 years for PMR. After a biologic called Actemra allowed me to taper off Prednisone, I haven't needed any Prednisone for 5 years. Now an endocrinologist is trying to reverse my metabolic syndrome caused by Prednisone.