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Neuropathy associated with Mounjaro use

Neuropathy | Last Active: Dec 28, 2025 | Replies (52)

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@projfan endocrinologist increased my dosage from 5.0 to 7.5 resulting in AMYOTROPHY or thinning paralysis. Lost 35 lbs in 6 weeks 17lbs of lean muscle mass. Left leg paralyzed for 4 weeks. 8 months later still recovering from massive muscle loss from lower back, buttocks, hips, thighs and calves. Lots of PT and supplements to work at getting back. Now able to walk but my gait still not right. Watch out, no warning about this. The pain is terrible, be very careful!

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Replies to "@projfan endocrinologist increased my dosage from 5.0 to 7.5 resulting in AMYOTROPHY or thinning paralysis. Lost..."

@chuckdux Good lord. How awful. I never hit that dosage -- I was a bit of a super-responder, meaning I lost weight at low doses, raised the dose really slowly due to side effects, and started ramping back down at a much lower dose. I know that there is concern about loss of lean muscle mass on these drugs, but that's spectacular confirmation. Glad the PT is helping! If you or your doctor did not think to report this experience to the FDA, you might want to consider it, since they collect this kind of data and your experience might help others. They have an online form for just this purpose.

I was waiting in a line the other day behind someone with walking poles, and asked about them -- I've been toying with getting some, and this was the first time I was in a position to chat with someone who uses them. He told me that once upon a time he was completely paralyzed from the waist down, and his PT recommended them in lieu of a walker as he gradually relearned to use his lower body. He said that the poles were especially advantageous because they help you maintain good posture and develop and support a normal gait. I suspect I will go there if I start falling more easily. It was a really supportive and helpful conversation.