@lsk1000 said, "Mine insists I remain on Orgovyx + Nubeqa for two years."

Yes, that's my friend's situation, PSA near zero, simple soft tissue location zapped with radiation and no metastasis seen, serious side effects from Orgovyx, but his oncologist recommended 18 months at the start and it's only been a year.

There are always concerns and "playing it safe" might be to stay on the ADT continuously, then again we want to see actual numbers, if the extra "safety" is on the order of 1% and the side effects are becoming overwhelming, you don't want the theoretical safety to keep you miserable when the odds are that you'll be fine with a break. And the perceived side effects suggest that real damage is being done so "safe" starts to lose its meaning.