@heidivet Good morning...I was diagnosed with uterine serous carcinoma in April 2021. It was picked up on a routine pap smear ( very unusual)...no symptoms at all. I fast tracked everything because I was told from the beginning that it was a rare and aggressive form of cancer. I has a total hysterectomy and was told that it was caught very early and had not spread beyond the uterine wall. I asked about chemo and radiation and was told that chemo would not prevent recurrence in the future and that brachytherapy was recommended. I had three treatments with radiation, very easy with no side effects. 18 months later the cancer recurred in my omentum and I had 6 rounds of chemo with carboplatin and paclitaxol. I tolerated the chemo well with few side effects other than loss of my hair, which wasn't fun but I found a great wig and looked good. After the 6 rounds I was NED (no evidence of disease). my hair grew back and I continued with a 30 minute infusion of herceptin every three weeks...no side effects from the herceptin , but have echocardiograms every 12 weeks because the heart can be weakened by the drug. In August of 2024 my CA 125 began to trend upwards...and yes again the cancer is back in a very very early stage..only seen in 2 lymph nodes in my pelvic region seen on a PET scan...My doctor told me that I could put off treatment until things got worse ??? or start with a targeted chemo drug called enhertu...I chose to start treatment in May of 2025...I have had 11 treatments and again I am tolerating the drug well with few side effects.......the infusion is 30 minutes as opposed to the 4 hour treatment of carbo...and I have been able to increase the time between treatments from 3 weeks to every 4 weeks......My PET scans have been NED so thew drug is working...ohhh I should mention that my cancer is HER2 + which is why enhertu is the drug of choice. I feel great and hate that I have cancer even when the scans show no evidence of disease because I know it is always lurking somewhere. My hope is that enhertu will continue to keep cancer at bay and that if it stops working there will be other drug therapies that will work.
I have a very active lifestyle and that has continued during my cancer journey that is going on 5 years with 2 recurrences. I hope that you are luckier than I have been with recurrence. I think you need to have faith in your doctors and if you don't find another. I am being treated at MSK in NYC. and I believe that I am in good hands . Good luck to you and happy holidays !

@heidivet I'm receiving the very same chemo with immunotherapy. Get the chemo. All it takes is one roaming cancer cell to plant itself and have a party. I was diagnosed with stage 3C endometrial cancer, possibly 4, and pathology confirmed I was stage 4. I am also HER2+ and am getting Herceptin with these 6 new treatments. I had my 10th total treatment last Monday. I still have 3 active lymph nodes so I'm not sure of treatment if they are still active after I finish. My PET scan says things are stable which means the chemo is keeping things in check but at the same time, my CA125 numbers went from 332 to 429 after 2 treatments. Quite a difference from the first time when they were 1641 and fell like dominoes down to 80 by the time I finished the first 6 treatments. It's a roller coaster. Get the chemo and be done with it. If you don't, you will always be wondering if any cancer cells escaped capture, and they are known to.

@heidivet I'm in exact same situation as you; diagnosed with Serous Endometrial Intraepithelial Carcinoma Stage 1a in June, with a few cells having invaded the musular lining. Surgery included a radical hystorectomy and removal of areas where the cancer was likely to have spread microscopically (like the omentum). One oncologist at MSK and another at UC Irvine said with a 20-30% chance of recurrence, just "wait and see" (no recommendation for chemo). However another doctor at UCLA said to do chemo so that recurrence is lessened by another 15%. I was thoroughly confused and went back and forth for months. Adding to the confusion were second and third opinions that kept changing my diagnosis; from precancer, to cancer only in the uterine lining, to a few cancer cells having gone beyond the uterine lining into muscular layer. I read as many posts as I could on sites such as this one and even discussed scenarios from the posts (thanks to people like alohman) with my oncologist. The UCLA doctor who recommended chemothetapy also gave me indepth studies to read and I reviewed them with the other oncologist who recommended wait and see. Through it all, with my brain totally exhausted, I ultimately decided to wait and see. My own logic was that no cancer was found anywhere else in my body, the areas where it was likely to exist microscopically were already removed, the extra 15% benefit did not guarantee non-recurrence nor outweigh the potential damage from the chemo itself, and it increased the chance of me becoming platinum resistent sooner if recurrences do happen later. I found many posts supporting both sides, so making this decision was really tough. I'll never know if it's best because if I do recurr, it could"ve recurred even with chemo. I just had to make a decision and stick to it. There's no clear right or wrong for people in our situation, unfortunayely.

@heidivet Don't be pressured. I won't go into my situation where I was pressured and in hind site I was pushed into something I didn't need. Keep reading here and research. Take a day to make any decision. Best wishes.