@heidi0974 No, I don’t think so. I have mild BE, and so far I’m not really tired from the disease unless I’m sick . Also, my 02 is generally good and doesn’t dip too much unless I’m sick . My biggest symptoms have been the thick mucus & constant coughing . Since Brinsupri , I’m producing less mucus, which helps me cough less. Also, the consistency of my mucus has changed - it’s rarely thick. I’m on 10mg. Good luck to you !!