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Epigenetic changes

Prostate Cancer | Last Active: 4 hours ago | Replies (11)

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Profile picture for surftohealth88 @surftohealth88

My husband had both tests done and it is good that you are doing this research since indeed some therapy choices can be adjusted depending of the mutations present in your cells.

Germline tests you can order for free. Here is the link for that discussion :
https://connect.mayoclinic.org/discussion/promise-registry-and-genetic-testing/
Somatic tests are usually ordered by your doctor - my husband's surgeon sent PC cells to be analyzed upon our request. My husband has 3 types of mutations on his cancer cells and none that are inherited. We did not get much information about his mutations since perhaps those mutations have no effect (as of now) for his treatment plan. He had localized cancer and so far only RP done.

You probably saw this article in your search, but just in case I will attach the link :
https://www.pcf.org/somatic-and-germline-genetic-testing-guide/wp-content/uploads/2025/10/PatientGuide-Testing-web.pdf
I wish you super successful treatment and please keep us posted since this is completely new area and new approach for PC treatment - that is why there is so little information available.

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Replies to "My husband had both tests done and it is good that you are doing this research..."

@surftohealth88 very helpful information- thanks!

@surftohealth88 I was thinking about you’re reply (that I appreciated) and wondered if it would make sense for you to request the specific information about the types of cancer cell mutations that they discovered. I’m personally no longer comfortable trusting medical advice that I can’t understand, research and ask informed questions about options. The good doctors are eager to educate (why I’m going to Mayo). I’m sure others are also good but too many, unfortunately, just paint by the numbers. As a retired chemical engineer who was focused on measurement, both qualitative and quantitative, and the associated pipeline flow issues; I’m appalled at how many doctors fail to treat you individually, based on All discoverable Facts, not just broad statistics (assumptions). (Sorry- soapbox)