ADT treatment and De Quervain tendonitis and stiff fingers

Posted by thierryb1959 @thierryb1959, Dec 20 11:10am

I am metastatic PC ,Gleason 9 moved to the bones. Started adt (Nubeqa and Eligard) treatment after, radiations and Doxetacel chemo in 2024. Now my PSA is = 0.1. I am glad. But I have developed stiff fingers (it is not arthritis) and De Quervain tendonitis is back hurting me after a damage that happen 30 years ago and that seemed to have been resolved. Anybody knows if ADT treatments are connected to these side effects and what to do about it beside seeing a rheumatologist? I play guitar so I am worried. Thank you.

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jeff Marchi | @jeffmarc | Dec 20 12:05pm

ADT can affect your joints.

Androgen Deprivation Therapy (ADT) for prostate cancer can significantly affect joints, causing issues like hand joint pain, stiffness, worsening physical function, and an increased risk of inflammatory conditions such as Rheumatoid Arthritis (RA) and other rheumatic diseases, partly by impacting testosterone levels that normally limit inflammation.

He was an article that discusses it
https://journals.lww.com/ursc/fulltext/2020/31010/prevalence_of_hand_joint_symptoms_in_androgen.5.aspx.

brianjarvis | @brianjarvis | Dec 20 1:01pm

Here’s a 2019 paper titled “Androgen deprivation therapy and the risk of tenosynovitis in prostate cancer patients” —> https://pubmed.ncbi.nlm.nih.gov/31111393/