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In praise of Orgovyx

Prostate Cancer | Last Active: Dec 20 10:56am | Replies (81)

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@jeffmarc re: "orgovyx does not directly kill cancer cells".

I believe I got the idea that ADT can kill cancer cells from a Prostate Cancer Research Institute video featuring Mark Scholz. I can't find the video right now, but I did find a paper PCRI put out that states the theory I thought I heard Scholz talk about. A percentage of prostate cancer cells are androgen dependent, and depriving them of testosterone kills them. I attached a graphic from the paper.

In the video I thought I heard Scholz state that something like what is depicted in the graphic happens in the more common type of prostate cancer. He commented that this means ADT starts a selective breeding process where the resistant cells end up being the predominant cells so that the tumors that grow back afterwards will be resistant to ADT. I thought what he was describing was an observation that this is how metastasized tumors become ADT resistant.

I don't know if this is a widely held view. I may be completely mistaken to think Scholz knows what he is talking about. Up until I saw his video I described ADT to myself as stopping tumor growth which I am very much in favor of. I guess I'm so much in favor of tumor death I didn't study deeply enough to be able be confident of my previous statement.

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Replies to "@jeffmarc re: "orgovyx does not directly kill cancer cells". I believe I got the idea that..."

@climateguy
When I posted this exact question in AI, it did come up with the exact words you are saying here. The weaker cells die and the stronger ones survive.

What bothers me about this is, it leaves open the possibility that any particular metastasis may have some of both types of cells and as a result, it never actually dies. Or does it completely kill off some mets and leave others.

I have heard about the fact that the more resilient cells have ability to overcome ADT And that results in what I have, castrate resistant prostate cancer. Definitely an uncertain long term solution.