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In praise of Orgovyx

Prostate Cancer | Last Active: Dec 20 10:56am | Replies (81)
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@climateguy

Orgovyx does not directly kill cancer cells. ADT doesn’t work that way.

Effect on Cancer Cells: Because prostate cancer cells generally require testosterone to fuel their growth, reducing testosterone to very low levels causes the cells to grow more slowly, stop growing, or shrink, but it does not necessarily kill them outright.

While it does not directly "kill" the cells in the traditional sense, this starvation method is highly effective at managing and slowing the progression of advanced prostate cancer.

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Replies to "@climateguy Orgovyx does not directly kill cancer cells. ADT doesn’t work that way. Effect on Cancer..."
climateguy | @climateguy | Dec 19 4:43pm

@jeffmarc re: "orgovyx does not directly kill cancer cells".

I believe I got the idea that ADT can kill cancer cells from a Prostate Cancer Research Institute video featuring Mark Scholz. I can't find the video right now, but I did find a paper PCRI put out that states the theory I thought I heard Scholz talk about. A percentage of prostate cancer cells are androgen dependent, and depriving them of testosterone kills them. I attached a graphic from the paper.

In the video I thought I heard Scholz state that something like what is depicted in the graphic happens in the more common type of prostate cancer. He commented that this means ADT starts a selective breeding process where the resistant cells end up being the predominant cells so that the tumors that grow back afterwards will be resistant to ADT. I thought what he was describing was an observation that this is how metastasized tumors become ADT resistant.

I don't know if this is a widely held view. I may be completely mistaken to think Scholz knows what he is talking about. Up until I saw his video I described ADT to myself as stopping tumor growth which I am very much in favor of. I guess I'm so much in favor of tumor death I didn't study deeply enough to be able be confident of my previous statement.

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