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44yr PSA180 Gleason9 non-metastatic. Surgery or Treatment?
Prostate Cancer | Last Active: Dec 19 11:46am | Replies (129)Comment receiving replies
Update 1 month on Lupron:
After 40 days on Bicalutamid 50mg, I was scheduled to get my first shot of Lupron (Trenantone 11,25mg 3-month depot). The day before the shot (01 Oct 2025), I got my PSA checked.
For those of you new to the trend, my initial PSA (mid August) was 180. Now it came back 33.
1 month into the Lupron, PSA 4.14.
I did change my diet drastically (no red meat, no dairy, no sugars, no coffee). Introduced a lot of veggies (mostly consumed raw). I am drinking soy, almond, or oat milk. I have experienced a lot with various forms of tofu. I also found a bunch of vegan dairy alternatives. One of them was an imitation feta cheese, that i had to read the ingredient several times because I could not believe it was made of vegetables (contained cocos milk). I could not make the difference between it and the real feta.
Now two weeks after the shot, I am not seeing any side effects.
I am working out daily, using one of those free at-home work-out apps. It gives me each day a routine of 20 minutes, and even if I am in a pretty good shape, I still break out a sweat. I also walk on average 12000 steps per day.
My PSA will be checked monthly and if it drops significantly after the first 3 months, I will go get RARP.
Psychologically, I am doing great, and i am actually looking forward to surgery.
The idea is to just go about with my normal life (work and family) and not really bother too much with the PCa.
Update 2 months on Lupron:
My PSA has gone up a bit from 4.14 last month to 5.35.
I am still doing all the dieting and the fitness from the previous month.
What i did additionally was to redo some of the blood works. What came back a bit outside of the norm were:
Hemoglobin 13.4 (13.8–17.2 g/dL)
Hematocrit 37 (42% to 54%)
All other values are withing the normal values. Any suggestions on how to combat the low levels?
Update 2 1/2 months on Lupron switching gear to Degarelix:
So after my 2 month PSA/testosterone levels sligthly spikes (5.3 PSA, 8 Test), i re-run the tests 2 weeks later. Results 11 PSA/4.1 Test.
The doct also performed an ultrasound and a DRE and noticed that the prostate has reduced its size as compared to the initial evaluation and it feels much "softer".
Then he switched me to Degarelix.
Initial application was today 2 shots of 120mg each (1 month depot) for a total dosis of 240mg. Follow up shot next month with a single 80mg shot.
Other than the disappointment with the results, i am in good moods and staying positive. Waiting to see how efficient the Degarelix is, and hopefully my values drop and i can get scheduled for the RARP.
To all Happy Holidays and a Happy New Year!
Replies to "Update 1 month on Lupron: After 40 days on Bicalutamid 50mg, I was scheduled to get..."
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@dinu
My hemocrit is 36.7 below the 39 for normal. You are real close. Not a big problem
My hemoglobin is 12.3 normal is 13.0 according to my lab. You are still normal, which is good.
That’s after eight years on ADT.
Disappointed your PSA is not going down any further, and actually rising a lot. Castrate resistance occurs when your PSA starts rising even though you are on ADT. I think it’s a little too early to consider you are in that condition, It usually takes years before that happens. It’s more likely your cancer is growing, even with the ADT. What does the doctor think? Have you asked them?’ I don’t understand what they expect to happen with a Firmagon shot. Your testosterone is already way down. Your PSA is going up, More than double. There’s not much more Firmagon can do with your testosterone so low already. It sounds like the doctor is shooting in the dark. Is there any way for you to get a second opinion?
When I had my surgery, they didn’t give me ADT first, They knew there was a problem and removed it. Why are they waiting? Your PSA more than doubling in 2 weeks should be a real warning.
That Firmagon shot can become painful over time. Orgovyx works just as well and is a pill You take daily. Maybe you can ask the doctor if it would make sense to switch you.
By now your testosterone is below 5. As the following information for AI shows, Once your Testosterone reaches castration level the affects are the same, So Orgovyx would be a lot easier on your body And you are at castration level. Results after one month of being on Firmagon will be quite revealing.
Both Firmagon (degarelix) and Orgovyx (relugolix) are effective GnRH antagonists that rapidly lower testosterone and PSA, but studies suggest Firmagon might offer slightly faster initial PSA reduction and potentially lower early PSA recurrence risk, though Orgovyx (relugolix) provides a convenient oral option, with long-term outcomes often similar for both once castration levels are achieved.