Epigenetic changes

Posted by zmarkv @zmarkv, 2 days ago

Who has been successful at tracking Epigenetic changes that drive prostate cancer progression.

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By successful, do you mean personally know how your DNA has allowed this to happen? There are 4 or 5 epigenetic changes that are known to be drivers of PCa, but I don’t think there is a way to tell you how or why your genes misfired.
They are able to detect these changes, just as they can with genomic testing (BRCA) but that’s about it. Hope that helps,
Phil

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Profile picture for heavyphil @heavyphil

By successful, do you mean personally know how your DNA has allowed this to happen? There are 4 or 5 epigenetic changes that are known to be drivers of PCa, but I don’t think there is a way to tell you how or why your genes misfired.
They are able to detect these changes, just as they can with genomic testing (BRCA) but that’s about it. Hope that helps,
Phil

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@heavyphil
So, are there tests that are standard parts of treatment plans?
Is there anything in particular do to, depending on what they show?
Are any such tests covered by insurance, or reasonably cheap, or even "home" tests you can do by mail?
Thanks!

REPLY
Profile picture for heavyphil @heavyphil

By successful, do you mean personally know how your DNA has allowed this to happen? There are 4 or 5 epigenetic changes that are known to be drivers of PCa, but I don’t think there is a way to tell you how or why your genes misfired.
They are able to detect these changes, just as they can with genomic testing (BRCA) but that’s about it. Hope that helps,
Phil

Jump to this post

@heavyphil I’m interested in learning what specific cancer cells are in play. As I understand, they change, explaining in part how they become castrate resistant or do not express psa that is normally tracked.

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Profile picture for carbcounter @carbcounter

@heavyphil
So, are there tests that are standard parts of treatment plans?
Is there anything in particular do to, depending on what they show?
Are any such tests covered by insurance, or reasonably cheap, or even "home" tests you can do by mail?
Thanks!

Jump to this post

@carbcounter yes, there are both somatic and genomic tests - I’ve had neither. Speak to your doctor or simply Google it.

REPLY
Profile picture for zmarkv @zmarkv

@heavyphil I’m interested in learning what specific cancer cells are in play. As I understand, they change, explaining in part how they become castrate resistant or do not express psa that is normally tracked.

Jump to this post

@zmarkv Honestly, I don’t understand the mechanisms are involved. There are papers on the NIH website that are deeply biochemical in nature; but they are so complicated I cannot follow them. Sorry!
Phil

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