@michhino
As of January 2026 it will be 10 years since I was diagnosed with idiopathic SFN. I spent one week at the Mayo Clinic in Rochester back in June of 2021 hoping they might find a cause, they didn’t. I retired from a major pharmaceutical company and know how to research and interpret clinical trial data. I have had 2 trials of a Spinal Cord Stimulators which failed. I have taken every drug out there and every test multiple times. The only neuropathy drugs I take are pregabalin, duloxetine and Low Dose Naltrexone 4.5mg. The drug I had high hopes for was an injection called Engensis from a South Korean company called Helixmith. I have tried for several years to get an update on the drug but the company went dark. YESTERDAY, I finally received a reply from someone that used to work for the company here in the United States, and he told me they had 2 Phase III trials that did not meet the primary endpoint. They also a a money issue in continuing the research. Basically the drug is very much DEAD.
There is nothing out there that will “cure” idiopathic SFN. IF they can identify a cause, then hopefully treating the cause will cure the neuropathy. I have never heard. Of someone actually curing neuropathy. The only drugs in trial now that I know of address the pain only (palliative) and none come anywhere close to a cure. For pain, the first non-opioid pain killer invented is a drug call Journavx. It has a very unique mode of action, and can be effective in pain relief for some patients. Other drugs with a similar MOA are in research as well.
My industry has done an amazingly poor job in their approach to neuropathy. They will develop tons of me-too drugs but have failed miserably at dealing with the degeneration of nerves and reversing it.
I am not offering any medical advice, but be careful what snake oil salesmen are selling. Desperate people sometimes lose their ability to reason logically when looking for help. I will advise anyone with neuropathy to exercise AS MUCH AS POSSIBLE with aerobic and resistance training if you can. I truly believe it has he with my discomfort. Good luck to all of us.