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It may be worth finding out whether your mother's breast cancer was estrogen receptor (ER) and/or progesterone-receptor (PR) positive, and whether either of you carries a BRCA mutation, to help refine your baseline risk. If those are negative, some observational data suggest that transdermal estradiol combined with micronized progesterone (bioidentical) is associated with relatively low additional breast cancer risk, especially over the first 5 years of usage, though not completely risk free and individualized assessment is needed.

It might also be worthwhile to discuss Duavee with your physicain, although long-term data is still limited.

Would love to hear what you find out.

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Replies to "It may be worth finding out whether your mother's breast cancer was estrogen receptor (ER) and/or..."

@mayblin Thank you. I know my mother took Tamoxafin so I believe it was an estrogen receptor positive breast cancer. I did get tested for BRACA1 and BRACA2 and fortunately I don't carry either of those genes. I'll look into Duavee!

@mayblin of note, the FDA hasn’t removed the black box warning from duavee