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@jeffmarc regarding your interest in studies of really high risk patients and EBRT + BT boost:

Here is a position paper based on a “comprehensive literature search”, that recommends EBRT + HDR BT boost therapy for men with “localized” intermediate and high risk prostate cancer. Some of the patients in the papers they looked at were T4, or NCCN defined “high risk”.

It starts: "The American Brachytherapy Society convened a task force for addressing key questions concerning prostate HDR brachytherapy boost with EBRT for the primary treatment of localized prostate cancer. "
https://www.sciencedirect.com/science/article/pii/S1538472125001175
There are 90 references.

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Replies to "@jeffmarc regarding your interest in studies of really high risk patients and EBRT + BT boost:..."

@climateguy
I’ve heard of people getting this treatment and it working quite well. It’s been reported in this forum actually, It’s been a long time, however. The last person had an Advanced case with cribriform. They had both IMRT and brachytherapy.

Interesting that the study in Japan did brachytherapy first then IMRT.

It is surprising that this is not done more frequently. I think it’s because of financial reasons, and I’ve heard that mentioned by Doctors. IMRT followed by Brchytherapy has been shown to be very effective for advanced prostate cancer cases.

Brachytherapy alone can be done in two sessions. That’s not as beneficial financially when you consider that SBRT is done in five sessions and IMRT/EBRT is done in 20 to 40 sessions. It seems that there are not enough places that do brachytherapy In the United States, Making it more difficult to find places that can do both treatments. In Europe, it’s quite popular, They are more interested in treating well than earning more off patients. When you have to cover everyone, it works better to have shorter treatments. I’ve heard that Canada also does a lot of brachytherapy. In many cases, they can just do brachytherapy, and that sure cuts down the amount of time a patient has to be directly involved with repeated radiation treatments.