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redlo avatar

What is next if Forteo does not work?

Osteoporosis & Bone Health | Last Active: Dec 20, 2025 | Replies (15)

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Profile picture for mayblin @mayblin

Hi redlo,
I have a couple of questions if you don't mind. Was the DXA you're using as baseline done before or after Fosamax? Also, when was the CTX of 750 measured? From what you wrote earlier, I wasn't completely sure of the timing.

It's quite possible that prior Fosamax use is contributing to the lack of measurable BMD change so far, even your bone markers showing good anabolic activity with Forteo. If you happen to get a newer P1NP at some point, would you mind keeping us updated?

Just to share my own experience: my response to Forteo was on the slower side too. After 13.5mo, my lumbar spine BMD was up about 4.9%, but there was essentially no change in BMD at the hips or femur necks. My P!NP at 13.5mo was very high (400+) showing great anabolic response btw. It wasn't until the second year and well into the antiresorptive phase when I saw much more noticeable BMD improvements across all sites. And that was without any prior treatment before starting Forteo.

From what I've read, newly formed bone matrix (osteoid) could take time to fully mineralize, so DXA changes could lag behind the responses we see in bone markers. In that sense, a flat scan results at this stage doesn't rule out meaningful improvement underneath.

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Replies to "Hi redlo, I have a couple of questions if you don't mind. Was the DXA you're..."

@mayblin
Thank you for responding and sharing.
Yes, my baseline dexa was after Fosamax.
April 2025 CTX 750
November 2025 CTX 1252
P1np June 2025 325
I go back in for my P1nP this week. I will post when I receive the results. I have to request the P1NP separately every time. They do not include it it on my on Quarterly blood work. It was McCormick that insisted I get it. Wish I had more confidence in my doctors here.

@mayblin
Hello
I Just got my p1np back yesterday. Little concerned it was 314 whereas June 2025 it was 325. I had a migraine when I took my blood test. Wondering if that could that affected the slightly lower score? Placed a call to have consultant with the McCormick . Distressed there won't be options for me.