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Macrolides contraindicated by tinnitus

MAC & Bronchiectasis | Last Active: Dec 15, 2025 | Replies (8)

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Profile picture for Jennifer, Volunteer Mentor @jenniferhunter

@wsbme74 I was harmed by high doses of Azythromycin. It caused ringing in my ears, then pain. I called the doctor at that point and was told to keep taking it. Then I lost all hearing in one ear and stopped the pills. It came back, and then the other ear went deaf temporarily. I do have hearing, but with tinnitus that varies. Allergies increase it.

I have used Mupirocin which is an ointment in my nose for sinus and lung infections that tend to reoccur. This was recommended as preventative for staph infection before some surgery I had at Mayo. It works great when I need it occasionally for my lungs. I have allergies and asthma.

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Replies to "@wsbme74 I was harmed by high doses of Azythromycin. It caused ringing in my ears, then..."

@jenniferhunter thank you for sharing that. It’s really helpful. I am sorry you had to go through that with your hearing/ears. Awful. I will definitely ask my doctor about mupirocin. I am a staph carrier (like so many people, from what I now understand) so it might really be a helpful tool. Thanks!

@jenniferhunter Can you say more about how you use mupirocin and when and how long?

In the past I've used it for crusting on the side of my nose and it works well. I have chronic sinusitis in addition to BE and asthma (and tinnitus). So far, Brinsupri has made a positive impact on both BE and CRS. And perhaps asthma. It's been under 3 months so difficult to say but things in me are improved.