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Macrolides contraindicated by tinnitus

MAC & Bronchiectasis | Last Active: Dec 15, 2025 | Replies (8)

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@wsbme74 Curious why they are waiting on Brinsupri? Based on frequent exacerbations you seem a likely candidate. I started it in mid-September; breathing, energy, sleep all much improved. I also have a history of frequent exacerbations but my sputum fails to grow anything treatable (normal flora etc).

The burning sensation in your chest -- might that be reflux/gerd? Unmanaged reflux can certainly cause frequent flares. With the asthma do you also have year round allergies?

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Replies to "@wsbme74 Curious why they are waiting on Brinsupri? Based on frequent exacerbations you seem a likely..."

@scoop hello. That’s wonderful that it’s having such a positive effect on you! Both pulmonologists seem to want to wait in general until there is a pool of evidence from longer-term use, I guess. They also want to look again at whether my asthma might be contributing more than it seems - so are speaking of a biologic first, which I haven’t done. I do have hypertension (seems to be genetic) and I understand Brinsupri can raise levels. I did have the 24-hour ph impediment test for GERD (what a horrid test!) and it didn’t really show reflux. But when I get the burning sensation, antibiotics kick it back almost immediately and it’s usually accompanied by other signs of a flare-up.