Aching legs from Orgovyx…. Oh yes!!! If I’m going to walk any distance I need a cane. (Just turned 80) but was in pretty good shape. We know the Orgovyx is doing its job by keeping my PSA and Testosterone level at “undetectable”. Was on Orgovyx for 6 months when I had to stop because of coronary issues. Orgovyx can exacerbate coronary artery disease. So after being off Orgovyx for just 9 weeks my PSA and Testosterone levels took a jump that was hard for me to believe. Testosterone returned to a normal level and PSA was climbing (forget the number). Back on Orgovyx and Oncologist thinks for maybe another year. Doing blood work every 3 months to monitor PSA & Testosterone, and the numbers are good so far. The leg pain is a problem and I’ll discuss at my next visit in a few weeks. Should it get any worse then that would be a major problem. Oh, I had 44 radiation treatments as well. Gleason score was a 7 (4+3) with seminal vesicle invasion. Cribriform, PI-RADS 5/5. Wishing everyone here much success with treatments. MERRY CHRISTMAS, HAPPY HOLIDAYS and a VERY HAPPY, HEALTHY NEW YEAR…. GOD BLESS. Ken