Hello @ginger55, welcome to Connect. You will notice that we added a little to your discussion title to help members who have tried low dose naltrexone (LDN) find and share their experience with you. I'm tagging @deborahyost3 and @suetex who have posted in other discussions about using LDN for treating Sjogren's.

While you wait for other members to respond I thought you might find it helpful to scan through the following discussion to learn what others have shared:
-- Sjögren’s Syndrome: how do you manage the symptoms?
https://connect.mayoclinic.org/discussion/sjorgens-syndrome/

Hi, @ginger55, glad to sing the paises of LDN. If you any lessining of the immune system give it a try. I know it works great for diarrhea and Crohn's. I was already on it when I found a doc that knew enough about Sjogren's to diagnose it so it would be hard to tell what effect LDN had on the Sjogren's. I know it was resposible for healing my small intestine. And that is enough reason for me.

I was on 2 mg and that is what healed my small intestine, (very small ulcers, very painful). My Nuerologist wanted me to increase the dose, but when I tried I couldn't tell any difference, so why bother? So I contenued like that for years even discouteuing my sufasalanene without incedent. Then I started to have diarhhea, but it didn't seem like my Crohn's. Then I went to 4 mg and all better, like turning a switch. So that is what I take now. I will report all this to my doc. Interested in his take on it. I have had no negetive reports to make.