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Discussions like this have led me to look for data that supports less ADT use.
Here is a video: "Radiation Dose and Hormone Therapy: How Much is Enough? with Dr. Nelson N. Stone, MD"


Dr. Stone starts the video stating that the current standard of care for high risk prostate cancer patients treated with radiation is 2 years of ADT.

He says he will explain why this needs to change in this talk.

Around minute 13 of the video he discusses the TRIP study, which took place in Japan.

This study gave each member of a group of high risk prostate cancer patients the same carefully measured total dose of combination external beam and brachy radiation therapy, then divided them into two groups.

One group got 6 months of ADT, and the other group got 30 months. The patients were followed for a median time of about 9 years.

The result was that there was no statistically significant difference in any measurable outcomes whether the patients got 6 months or 30 months of ADT.

He concludes that this study suggests that the most important factor influencing freedom from progression of prostate cancer after RT is if the total delivered radiation dose is high enough.

And if the total delivered radiation dose is high enough, there is a reduced need for ADT, i.e. 6 months is enough.

The total dose of radiation that all patients received in this study can only be delivered safely with a combination of external beam and brachytherapy.

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Replies to "Discussions like this have led me to look for data that supports less ADT use. Here..."

@climateguy
interesting study. I’ve heard the combination of IMRT/EBRT and brachytherapy is really the ideal for advanced prostate cancer. I’ve heard of a number of people getting it, but never seen a study (now the Trip study) that showed that it was the optimal way to do it. Interesting thing is the study did brachytherapy first and EBRT second, Something I’ve never heard of anybody having. It’s always been the other way around.

I wonder if it would make a difference.

The study didn’t seem to take into account, very advanced cases, however. The criteria was T2c-3a, or a prostate-specific antigen (PSA) >20 ng/ml or a Gleason score >7.

Why didn’t they include T3b it T4?

I sure would be interested in seeing the results of a trial that worked with more advanced cases. These were just somewhat advanced.