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@cbusgma2017
At the most basic level you can't remodel bone without osteoclasts. Evenity works primarily by blocking osteoclasts just like the bisphosphonates and Prolia, all three by different methods.
We've come to think of osteoclasts--the cells that break down bone as the enemy. But osteoclasts don't break down bone at random. They are attracted to sites where the bone is weak, damaged, fissured. (As much as I dislike metaphors) you would never wax your floor or your car without cleaning it first. Medications that block the osteoclasts are doing just that to your bones. Leaving damaged portions underneath the new fresh bone. Those damaged portions have lost vascular and nerve viability. So you have encased in the new bone the potential for osteonecrosis.
Chrondrocytes need sclerostin for maintenance and development. Chondrocytes necessary for the production of collagen. Because the PTH drugs increase the production of chondrocytes they are able to rebuild the cartilaginous pre-structures that are needed to replace lost trabecular bone. Evenity blocks sclerostin.
Within joints you lose also lose the extracellular matrix for maintenance joint function. Without sclerostin, cartilage becomes bone in the form of bone spurs.
Evenity does add bone between the periosteum and the endosteum. Sometimes where there had never been bone before. Heavy thick bone and if you measure strength by density alone, you'll believe heavier is stronger.

But the whole purpose of osteoporosis medications is to prevent fracture. And all of these medications are effective for some and ineffective for the few.

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Replies to "@cbusgma2017 At the most basic level you can't remodel bone without osteoclasts. Evenity works primarily by..."

@gently
This makes tremendous sense to me. Preventing osteoclasts from doing their "clean up" operation while super-charging osteoblasts to create new bone does sound like it would wax over the dirt on the floor. Also, from my naive perspective, doing something like building bone in slower motion (over 12-24 months) seems like a better approach than growing it super fast (< 12 months).

But folksy images ain't science! I trust the research (though slow-and-steady-wins-the-race images might help keep my spirits up over the next 12-24 months of potentially unpleasant side effects).

Thanks for your posts on this @gently. They help a lot.