Thank you for asking! In the area of breast cancer, I am interested in hearing about patients who limited treatment because of age, co-morbidities, and/or personal preference. For example, frail elderly patients who turned down chemotherapy. Or shorter courses of radiation. Or refusal of aromatase inhibitors due to side effects. Did limiting treatment, perhaps to 3 out of 4 suggested modalities, have any significant effect of survival interval or life expectancy? Not asking about alternative treatments or psychological approach or lack of compliancy but a clear decision communicated to oncologist.