I have just started Repatha two months ago and I have had serious leg cramps twice this week so far. I did this with last statin after I had taken for 3 months without any side effects until the cramps. The lab work completed last time with the statin showed elevated creatinine and I stopped the statin, leg cramps went away. These leg cramps associated with the statin are like nothing I have ever had so I do believe it's repatha related. I doubt this will be the last leg cramps since repatha half life is 11-17 days and I took my last injection 7 days ago. I have tried 3 statins and zetia, and have been either intolerant or allergic to all of them. I have messaged my doctor for advice.