I have been taking Orgovyx 6 months and have had some aches and pains but mostly very transient and not at all severe enough for opiate pain killers- just an Aleve now and then.

I think your friend needs to go back to oncologist and maybe MRI and see if there is bone involvement from the PC- I hope not. other possibility is hip/bone damage from osteoporsis? or fall...

Lastly, usually ADT is given before radiation : 'ADT (Androgen Deprivation Therapy) typically starts before prostate radiation (neoadjuvant) to shrink the tumor, reduce cancer cell growth (since testosterone fuels them), and sensitize them to radiation, making radiation more effective and improving survival, especially in intermediate-to-high-risk cancers, by weakening cells and preventing DNA repair, with benefits seen in shorter pre-radiation courses. '

xahnegrey40, thanks.
As I understand the story he'd been watching his PSA in the danger zone for several years and then about a year ago it spiked up, he was further diagnosed and sent immediately for radiation, and afterwards started ADT, but I'll check back on that. Don't believe they found any bone involvement at that time.

He's had various aches and pains for many years but not diagnosed with anything, was still doing a fair amount of running up to a few years ago, last marathon (or half?) was, oh, must be a while now, maybe around age 70+? But very little to none in the last year. He's out and about every day just not as athletically as before.

He's not talking to a lot of people about this but I've talked nutrition and general health with him often enough for many years. I will also see if his PCP is referring him back to the oncologist as you suggest. Thanks for your suggestions.

I had shin pain that lasted a few days when I was on Orgovyx. It went away as mysteriously as it came on and I never had bone pain again throughout my 6 months on ADT

ADT doesn’t kill off the cancer it shrinks it and stops it from spreading but when you stop ADT it can come right back.

ADT is known to cause joint pain. Doesn’t matter whether you are on Orgovyx, Lupron, Eligard, Firmagon Or any of the other drugs that reduce testosterone.

Here’s some more detailed information on the effects of ADT.

Androgen Deprivation Therapy (ADT) for prostate cancer commonly causes joint pain (arthralgia) due to lower testosterone affecting bone and muscle health, leading to inflammation, bone density loss (osteoporosis), increased fracture risk, and potential development of rheumatoid arthritis, with exercise, NSAIDs, vitamin D, and bisphosphonates being potential treatments to manage these musculoskeletal side effects.

I was on Lupron for a year then off for a year. I'm now in month 8 of another round of ADT. After 6 months of Lupron I decided to switch to Orgovyx for various reasons. I have been suffering from increasing peripheral neuropathy in feet for some time which can be attributed to degenerative disc disease, but also to ADT. In the last week (8 weeks now on Orgovyx) I've developed rather severe pain in my one ankle which I was attributing to neuropathy but now seems more likely joint related and maybe we can blame on Orgovyx. Interestingly, the morning pain and hobbling for an hour (mentioned above) is exactly what I'm experiencing, and also what many of us have experienced with plantar fasciitis, but for me in the ankle not the heel.
I'm seeing my PCP today and trying to connect with my Urologist.

I was on ADT for a year. It took being off of ADT for 18 months before my severe joint pain faded. My pain in my knees, elbow, and back were also the places where arthritis had been identified before I started ADT. ADT does not kill cancer, radiation does. However, cancer stem cells can escape and remain dormant in local or distant locations. Turkey Tail mushroom tea does kill cancer stem cells. I take a cup of the tea daily. For the last four years my PSA has hovered around 0.08.

Aching legs from Orgovyx…. Oh yes!!! If I’m going to walk any distance I need a cane. (Just turned 80) but was in pretty good shape. We know the Orgovyx is doing its job by keeping my PSA and Testosterone level at “undetectable”. Was on Orgovyx for 6 months when I had to stop because of coronary issues. Orgovyx can exacerbate coronary artery disease. So after being off Orgovyx for just 9 weeks my PSA and Testosterone levels took a jump that was hard for me to believe. Testosterone returned to a normal level and PSA was climbing (forget the number). Back on Orgovyx and Oncologist thinks for maybe another year. Doing blood work every 3 months to monitor PSA & Testosterone, and the numbers are good so far. The leg pain is a problem and I’ll discuss at my next visit in a few weeks. Should it get any worse then that would be a major problem. Oh, I had 44 radiation treatments as well. Gleason score was a 7 (4+3) with seminal vesicle invasion. Cribriform, PI-RADS 5/5. Wishing everyone here much success with treatments. MERRY CHRISTMAS, HAPPY HOLIDAYS and a VERY HAPPY, HEALTHY NEW YEAR…. GOD BLESS. Ken