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When to seek a 3rd opinion?

Liver Cancer | Last Active: Dec 13, 2025 | Replies (14)

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I say "nuke" instead of nuclear, it means I am injected with radioactive material. As soon as my AFP started elevating (to 56), my NP gastroenterologist sent me for an MRI. That was April 2024 and there were no lesions present. The next AFP was 2400 and that was November 2024, and a .9 cm lesion was found (the MRI reports are inconsistent about measurements for some reason, I said yesterday it was mm but it's cm). My NP sent me to an Interventional Radiologist, and she has been treating me ever since. Both of them read an elevated AFP as a warning sign of HCC, especially with my Hep C history. Also they are finding that even if the virus is cleared, there is still a chance of liver cancer. Since a tumor so small would not produce so much tumor marker, they sent me to a series of other scans to look for a primary cancer, none was found. No metasteses was found. Then they recommended radioembolization Y-90, which ultimately was cancelled due to the Tumor Board's decision. The Tumor Board has oncologists and various specialists. My next MRI will be in January 2026. I had thought about seeking another opinion from a cancer center or hepatocellular oncologist. I am not hardy enough to travel, so I would either go to a doctor here or via telehealth. I reached out to this discussion group because I found a discussion about Y-90 on it.

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Replies to "I say "nuke" instead of nuclear, it means I am injected with radioactive material. As soon..."

@ginkle999 Do you know what radioactive material you were injected with? I don't understand the roles of your care team. For example, I was diagnosed with stage 4 pancreatic cancer in 8/22. It spread primarily to my liver and bones. Treating my liver has been just as important as my pancreas. My liver had innumerable lesions with the largest being 8cm. I have the support of a multidisciplinary team that includes healthcare professionals from primary care, oncology, cardiology, pulmonology, hepatology, and others. They each have defined roles but collaborate to provide me with the best care possible. Most tumor boards are similar. In my experience, the lack of defined care team roles leads to confusion in diagnosis and treatment. If you don't feel comfortable with your current care, I highly recommend getting as many opinions necessary until you do feel comfortable. Use the process to interview healthcare professionals and assemble the best care team for you. Let's hope your lesion is benign and further care isn't warranted. But, it never hurts to have an alternative plan in place and a team assembled should the need arise. Make sense?

If you are interested in getting another opinion from Mayo, here is a link to initiate that process. https://mayocl.in/1mtmR63