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Replies to "@jiffaw I think there is more a genetic link than people realize. Something triggers that gene,..."
Polymyalgia Rheumatica (PMR) | Last Active: 19 hours ago | Replies (26)
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@jiffaw
I think there is more a genetic link than people realize. Something triggers that gene, probably trauma from a wound or infection, and sets it in motion. Seems so unfair that most people on here who have led healthy lifestyles seem to be a target for this nasty disease.
Replies to "@jiffaw I think there is more a genetic link than people realize. Something triggers that gene,..."
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@caroljeand
If PMR is anything like Reactive Arthritis (ReA) then there is a genetic predisposition that is triggered by an infection. The following link was updated recently.
https://www.ncbi.nlm.nih.gov/books/NBK537274/
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"Familial aggregation of PMR has suggested a genetic predisposition.[1] HLA class II alleles are found to be associated with PMR, and among these, the HLA-DRB1*04 allele correlates most frequently, seen in up to 67% of cases.[2] Genetic polymorphisms for ICAM-1, RANTES, and IL-1 receptors also appear to play a role in the pathogenesis of PMR in some populations.[3]
There were reports of increased incidence of PMR along with GCA during epidemics of mycoplasma pneumonia and parvovirus B19 in Denmark, suggesting a possible role of infection in etiopathogenesis.[4] The Epstein-Barr virus (EBV) has also been proposed as a possible trigger for PMR.[5] However, several other studies have not supported an infectious etiology hypothesis.[6][7]
There are also reports of an association between PMR and diverticulitis, which could suggest a role of a change in microbiota and chronic bowel inflammation in the immunopathogenesis of the disease.[8]"