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44yr PSA180 Gleason9 non-metastatic. Surgery or Treatment?
Prostate Cancer | Last Active: Dec 19 11:46am | Replies (129)Comment receiving replies
Update 1 month on Lupron:
After 40 days on Bicalutamid 50mg, I was scheduled to get my first shot of Lupron (Trenantone 11,25mg 3-month depot). The day before the shot (01 Oct 2025), I got my PSA checked.
For those of you new to the trend, my initial PSA (mid August) was 180. Now it came back 33.
1 month into the Lupron, PSA 4.14.
I did change my diet drastically (no red meat, no dairy, no sugars, no coffee). Introduced a lot of veggies (mostly consumed raw). I am drinking soy, almond, or oat milk. I have experienced a lot with various forms of tofu. I also found a bunch of vegan dairy alternatives. One of them was an imitation feta cheese, that i had to read the ingredient several times because I could not believe it was made of vegetables (contained cocos milk). I could not make the difference between it and the real feta.
Now two weeks after the shot, I am not seeing any side effects.
I am working out daily, using one of those free at-home work-out apps. It gives me each day a routine of 20 minutes, and even if I am in a pretty good shape, I still break out a sweat. I also walk on average 12000 steps per day.
My PSA will be checked monthly and if it drops significantly after the first 3 months, I will go get RARP.
Psychologically, I am doing great, and i am actually looking forward to surgery.
The idea is to just go about with my normal life (work and family) and not really bother too much with the PCa.
Update 2 months on Lupron:
My PSA has gone up a bit from 4.14 last month to 5.35.
I am still doing all the dieting and the fitness from the previous month.
What i did additionally was to redo some of the blood works. What came back a bit outside of the norm were:
Hemoglobin 13.4 (13.8–17.2 g/dL)
Hematocrit 37 (42% to 54%)
All other values are withing the normal values. Any suggestions on how to combat the low levels?
Additionally I have had genetic testing done. While i was expecting mutations in the BRCA1/2, or TP53 genes, it came out that I have a mutation in the ATM gene. My mother had breast and stomach cancer (now all clear), but according to the discussion with the folks from the genetic dept. the ATM gene mutation only increases my risk of cancer slightly (?!). Luckly i only have 1 of 2 pairs affected. Even though my father had PCa.
ATM could also come from my military exposure in various combat zones plus the ship deployments, combined with the fact that I worked as an industrial radiographer for 11 years.
I read that the most effective treatment is ATR with PARP. What exactly is ATR?
I will discuss all these topics with my doctor next week, but i would appreciate your thoughts
Replies to "Update 1 month on Lupron: After 40 days on Bicalutamid 50mg, I was scheduled to get..."
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@dinu
Good to hear you’re feeling well. Not really pleased about your PSA rising, But you haven’t had the primary treated yet.
Have you had your testosterone checked? That is really critical for keeping your PSA down. You should make sure to get a testosterone test the next month.
Has your RBC count also going down. I’ve got the same hemocrit and HGB thing you’ve got, had it for years. The only thing you could do to stop this is stop ADT, Don’t worry about it it’s minor, Right now. Be aware that a PARP inhibitor can greatly reduce hemocrit, HGB, WBC and platelets. My oncologist has had me hold off on getting a PARP For at least five years because it is so hard on the system.
Must admit I’ve never heard of the ATR with PARP Treatment, And I know PARP has not worked well with ATM, but maybe that is the answer. Here is an article about it.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11934101/.
There’s no reason you can’t have coffee. I’ve had one cup a day for years.
Your father having prostate cancer, doubled your chance of getting it and have an ATM issue on top of it, that means that you get it younger like I did With the father and BRCA2 combo. Your comments about one out of two pairs matches mine. I got BRCA2 from my mother and my father didn’t have it, but had prostate cancer.
Hereditary genetic issues do not occur from Environmental issues, They only occur because of inheriting them from a family member. The fact that you got PC so young could also be due to the environmental issues.
Almond milk isn’t really good compared to soy or oat milk. Soy milk has the most protein, which is one thing you need when you have prostate cancer and are taking ADT. You need the protein to keep your muscles strong. Hopefully you’re getting a significant amount of protein every day with the diet you’ve picked. I eat chicken or fish almost every day and even put chicken or seafood in my salad to boost the protein. I also eat high protein cereal in the morning. That helps with keeping your muscles up because of the deteriorating effect that ADT has.
Actually, your PSA rising is a good reason to get the RARP. You’re letting the cancer fester in your prostate and that could be causing the PSA rise, Hopefully, it’s not because it is metastasized to other spots in your body.
Have you had a PSMA pet test? The CT scan is sort of worthless at this point, you need a pet scan to find out if the cancer is spread anywhere else in your body. The rising PSA is not a good sign and could mean that it is spreading. Your high PSA will allow the pet test to show everything going on in your body.
Hoping for the best in the future for you.