@margitdill Hi I too am on Enhertu. I'm having my 11th treatment tomorrow...I've increased the time between treatments from every 3 weeks to 4 weeks because I don't like feeling poorly. I am fortuante to be tolerating it pretty well, no nausea though appetite is not great for about 10 days, bladder control is definitely not as good as it once was, bowels ok, fatigue only in the afternoon on day 4and 5..... I have a very active lifestyle and for the most part I have been able to keep up with my pilates and pickleball. After 14 days I feel 100% like myself...so I have 2 weeks of feeling great. I was losing a lot of hair, but that seems to have stopped, which I am happy about because I have short hair and can't afford to lose morewwithout looking like I need a wig! My nest scan is in February so hopefully it will be NED and increasing the treatments to 4 weeks will not have had a negative effect. If all is good in February, I may decrease the dose as well.....I'm told that treatment with Enhertu had no end date...so if I am going to be continuing, I'd like more time feeling good ! I'm also told that if Enhertu stops working there are other drugs ??? I remain optimistic and hope only good results for us all !!!!!!!