Thank you for trying to confirm some of my concerns. It states on Drugs.com that chemo and radiation may increase the risk of osteonecrosis. When I was a dietitian and charting at the desk in each unit, the first thing the doctors did every morning was to check their drug stocks. I think they are defending these drugs to increase their own assets. I left a call with the Amgen side effects department due to the edema. My legs are so swollen, and it is not my heart per the cardiologist. Thanks for all of the info on your supplements and diet.