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Enhertu treatment and quality of life

Gynecologic Cancers | Last Active: Dec 11, 2025 | Replies (30)

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@margitdill I’m in a similar diagnosis, also with limited treatment options and feeling unhappy about my quality of life on ENHERTU. I get my 1st CT tomorrow after 3 rounds on it. You’re not alone in your side effects and questions about what’s next if not ENHERTU.

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Replies to "@margitdill I’m in a similar diagnosis, also with limited treatment options and feeling unhappy about my..."

Thank you for sharing this. I think I’ve 6 rounds of ENHERTU now … the last 2 were reduced doses. It was by far the worst chemo drug I’ve had. I thought TIVDAK was bad … ENHERTU was worse. They’ve scheduled my next reduced dose on Dec 22. Probably have another scan then. My doc has an off label drug he thinks will be good for me. I will get the name of it and post it. With this last reduced dose, there were fewer side effects. But ENHERTU was still rough on my bladder and its function.

@bonham27 Welcome to Mayo Clinic Connect and to our Gynecological Cancers Support Group. If I figured this correctly then you are getting the CT today (Dec. 8). Is that correct? Will you talk with your oncologist after the CT so they will know (if they don't already) how your quality of life is on ENHERTU?