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Hi, My Husband was diagnosed with PDAC in June 2025. Fortunately operable T1N0M0. He completed 9 rounds of Neoadjuvant Flofirinox and had a Whipple completed 2 weeks ago. He is home but he is struggling with appetite and weight loss, has lost 25 lbs so far. Doesn’t want to eat, says everything tastes poorly. He is on Creon and his dose recently was increased. Hoping to find ideas of how to help manage. Thank you.

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Replies to "Hi, My Husband was diagnosed with PDAC in June 2025. Fortunately operable T1N0M0. He completed 9..."

@yellie welcome to Mayo connect!

So happy you joined us 💜

I had the whipple and can relate to some tough symptoms like nausea, and weight loss. I have or had stomach aches whether I eat or not, and cramps.

If you can, help him find ways to eat what he feels comfortable with. If he’s struggling to get enough protein, maybe suggest trying a protein drink to boost his nutrition. Or try a homemade smoothie. You can create simple recipes that provide extra protein and or calories to help support his health and wellness.

It’s important that his weight stabilizes.
He should probably be seeing nutritionist if he’s not already.

He might not be up for eating regular-sized meals, so having several small meals throughout the day could be a good idea.

Things should improve with time.
https://connect.mayoclinic.org/discussion/significant-changes-in-food-taste/
Take care 😊