Has anyone had success taking Alpha lipoic acid for neuropathy?

@ccchang HMS brand ALA-R from Walmart. It's in a red bottle, 300mg, 60 capsules. B-12 not sure about but I take 2 a day.

@ccchang
I actually get my vitamins and supplements from Swanson’s Health Products online.
Have used them for years with good results !!

@janekwick Thank you!

@carol1024 Thank you!

I was told that taking Alpha Lipoc acid with Benfutimiene 4 times a day was helpful for neuropathy!
HAS ANYONE TRIED THIS COMBINATION!
Fran

I had an allergic reaction to it. My kidneys quit working and I quit urinating. It hurt my kidneys and damaged them. I got gripped out by the neurologist not a proven treatment in the US. Germany since 1965 has used the IV Alpha Lipoic Acid and in the article says pills do not work as well. Just be careful on it. I am highly allergic to sulfa, sulfites and sulfonamides and the pharmacist said it didn’t have any sold products in it. It does. Try the R-alpha lipoic acid it can be ordered online or by your pharmacist at your pharmacy.
https://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid
My neuropathy caused by my autoimmune disorders I am Not diabetic. I have lupus, connective tissue disease, sojourns, Hashimotos, ehlers danlos.

Alpha-lipoic acid (ALA) shows promise for remyelination, primarily by acting as a powerful antioxidant and anti-inflammatory agent that protects nerves, reduces immune cell damage to myelin, and may promote myelin repair in conditions like Multiple Sclerosis (MS) and diabetic neuropathy, with research highlighting its ability to upregulate myelin proteins and protect against oxidative stress, though more clinical trials are needed to establish optimal dosages and effectiveness.
How ALA May Promote Remyelination
Antioxidant Effects: ALA neutralizes harmful free radicals, reducing oxidative stress that damages myelin sheaths.
Anti-inflammatory Action: It reduces inflammatory markers (like TNF-α) and decreases immune cell infiltration into the brain and spinal cord, lessening autoimmune attacks on myelin.
Promotes Myelin-Making Cells: Studies suggest ALA can stimulate oligodendrocyte precursor cells (OPCs), the cells that create myelin, helping them mature and repair damaged sheaths.
Neuroprotection: It helps preserve nerve fibers, a crucial step for successful remyelination, and may prevent nerve cell death (apoptosis).
Evidence & Research
Animal Models: Studies in rats with induced demyelination show ALA reduces myelin loss, increases myelin protein expression, and improves nerve function.
Human Trials (MS): ALA has shown potential to reduce disability and slow disease progression in MS, though results vary, and it's not a cure.
Diabetic Neuropathy: ALA has demonstrated effectiveness in delaying or reversing diabetic neuropathy by reducing nerve damage.
Clinical Trials (OCTOPUS): Larger trials are ongoing, like the OCTOPUS trial, to test ALA and metformin's combined effects on disability and remyelination in progressive MS.
Key Considerations
Not Approved for MS: ALA is an investigational treatment for MS and not yet a standard therapy.
Dosage & Form: Typical doses studied are around 600mg, sometimes twice daily; the R-form might be more effective, and it's best taken without food.
Consult a Doctor: Always discuss ALA supplementation with a healthcare professional before starting, as it can have side effects like GI upset.

@artemis1886 I do use the R

@artemis1886 ChatGPT??

I use alpha lipoid acid all the time. It does help. I take 600mg now, I think I need to increase it again. Why does it feel like I have socks on. Weird feeling. all the time, never lets up.