@thnx4beingthere, to be honest, I didn’t feel anything for the first few days after taking the loading of ORGOVYX. No hot flashes, nothing. I deliberately waited seven days before I started my generic Zytiga. The point of both drugs is to deprive your body and the cancer cells from testosterone and when my testosterone plummeted, I did experience some nausea, but my doctor had prescribed Compazine, which worked quickly to stop the nausea. I’ve heard good things about about Nubeqa. I hope you get great results! Good luck on your journey.