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@swalex IV colchicine works on systemic inflammation also not just with gout. They use it in heart inflammation cases. My blood work, other than listed above, comes back normal. I think kidney issues would create consistent issues not show up in just different joint areas. Plus the severity of the muscle pain and stiffness is better although still present then will get sharply worse. I will ask dr about though. Thanks

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Replies to "@swalex IV colchicine works on systemic inflammation also not just with gout. They use it in..."

@jimgill

I have had similar symptoms for the past 2.5 years with diagnosis of systemic sclerosis or scleroderma. It is diagnosed by blood test SCL-70. The main source of inflammation is coming from vasculitis throughout the body, which is causing chronic fatigue, joint stiffness, and GI distress. Another hallmark of scleroderma is skin thickening. But joints/GI inflammation and fatigue may start 1-2 years before actual skin thickening becomes obvious. For this reason, the diagnosis is frequently missed until the doctor will see skin thickening. The symptoms you are describing (sudden onset of muscle and joint discomfort) mainly coincide with food intake, particularly solid, fried, and acidic foods. You may have a different autoimmune condition possibly associated with GI. May be worth checking with gastroenterologist. Best regards