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jimgill, you may have given us a few clues. Your skin issues hands and thighs sound like psoriasis. The joints may be affected by psoriatic arthritis as they are often seen together. A dermatologist may be able to determine by looking at your skin during a flare, if not they should offer a biopsy.
ANA 1:80 is high but is common in people without autoimmune systems. The follow up to a positive ANA would be an ENA which could help to determine if and which autoimmune system is activated in you.
There a many medications topical and injectable which can relieve symptoms. If you have psoriatic arithritis you would want to protect your joints from the permanent damage they can cause.
I'm curious about how you will proceed.
Sarcopenia can be counteracted for some extent by careful attention to nutrition. Creatine supplements, D3 supplementation, sufficient protein intake for your weight and exercise can help.
I'd try to get the ENA from whomever ordered the ANA. If your internist isn't helpful, you might want to see a rheumatologist. I'd see a dermatologist as well. If the dermatologist can't tell by looking, ask for the biopsy.
Best wishes.

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Replies to "jimgill, you may have given us a few clues. Your skin issues hands and thighs sound..."

@gently thanks for the recommendations. Derm Biopsy wasn't conclusive : could be this could be that. I will get the ENA ordered. I have seen rhem DRs at Jefferson and John's Hopkins. Head rhem Johns said def auto immune he just didn't know which one. This was years ago. Complement C3 is also high. Other people may have 1:80 but don't have the inflammation and other symptoms I have. Why would the joints or ligaments get inflamed literally you can see they are swollen and hit to touch then within 48 hours go away? I have what is fairly severe very limiting muscle pain and stiffness. If I do a squat Somedays I can stand back up other days my legs just won't accomplish. I do the non inflammatory diet. I take supplements.