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Continued hormone therapy? or not?
Prostate Cancer | Last Active: 15 hours ago | Replies (12)Comment receiving replies
Hey @jeffmarc
"With a 3+4 they usually don’t recommend any ADT."
Would they usually recommend ADT for 4+3?
Replies to "Hey @jeffmarc "With a 3+4 they usually don’t recommend any ADT." Would they usually recommend ADT..."
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@web265
In my case they didn’t, after surgery. I was a 3+4 before surgery and a 4+3 after. I went 3 1/2 years after surgery before my PSA started rising. Pretty sure ADT would not have been given to me that long if they did recommend it.
Below guidelines, highlight the fact that in your case, you would need two of these three things before ADT would be recommended. PSA 10-20, GG2 or 3, T2b-c. So, where do you fit Based on your past history?
Here are current NCCN Guidelines in 2025. They now suggest 0 (zero) months of ADT for low intermediate (GG2); 4-6 months for high intermediate (GG3), and 18-36 months for high risk (GG4 and 5). Actually, the footnote suggests ADT + abiraterone for T3b with lymph node involvement.
The meta-analysis suggests:
* 0 months for 1 intermediate factor (PSA 10-20, GG2 or 3, T2b-c)
* 6 months for 2 or more intermediate factors (PSA 10-20, GG2 or 3, T2b-c)
* 12 months for NCCN high risk (PSA >20, GG4 or 5, T3 or 4)
* undefined for NCCN very high risk (2 or more PSA >40, GG4 or 5, T3 or 4)