Replies to Researchers (from University of Leipzig, Germany and Shandong University, China) identified GPR133/ADGRD1 as a receptor that...

← Return to Possible good news on availablity of LIFTMOR/ONERO program in U S

Discussion

Possible good news on availablity of LIFTMOR/ONERO program in U S

Osteoporosis & Bone Health | Last Active: Dec 3, 2025 | Replies (12)

Comment receiving replies

@bonebuddiesforlife

Researchers (from University of Leipzig, Germany and Shandong University, China) identified GPR133/ADGRD1 as a receptor that plays a central role in bone formation and maintenance.

Has anyone in the thread read or heard about this study ?
My specialist is trying to strong arm me into going on Jubbonte after a year on Evenity and I am not convinced this is the right next step.
In a 58 year old male , very active in the gym with weights and cardio and a very good high calcium diet.
I would like to know why my bone density is breaking down not just go on the next available drug , be that is hard to transition off of .

Jump to this post

Replies to "Researchers (from University of Leipzig, Germany and Shandong University, China) identified GPR133/ADGRD1 as a receptor that..."

njhornung | @normahorn | Dec 2, 2025

@bonebuddiesforlife

See https://connect.mayoclinic.org/comment/1451232/

VIEW AND REPLY

oopsiedaisy | @oopsiedaisy | Dec 2, 2025

@bonebuddiesforlife Has your specialist investigated any hormonal issues? Bone density issues in men can be related to a decline in testosterone.

My dad had osteoporosis that went undiagnosed as it was in a time before DEXA scans. He had many fractures over the years, starting in his 50s. He died at age 75 and was very stooped and frail. He never smoked or drank and was lean and physically fit for that time. He liked to run but didn't lift weights.

I (64F) also have osteopenia/osteoporosis that started in my early 50s despite a healthy lifestyle (good diet, lifting weights, cardio, etc.). I wonder if it's mostly due to genetics because of my dad. I am also currently on Evenity and my doctor is also recommending Prolia (Jubbonti) when I finish it.

I have fractured once already and am eager not to go down the same path as my dad so I am considering it. I would only do a year on it then go to Reclast.

It would be nice not to have to take any medications but I don't think that's viable for me as doing all the right things did not prevent bone loss and fracture.