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Ubiquinol (CoQ10) Supplement

Headache & Migraine | Last Active: Dec 3, 2025 | Replies (6)

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Profile picture for Lisa Lucier, Moderator @lisalucier

Tagging a few Mayo Clinic Connect members who may have some knowledge of or experience with CoQ10 for migraine @rwinney @chell926 @erin38. Perhaps if they have taken it personally, they can comment on if CoQ10 has helped? If so, how much did you take? Was your doctor on board with your taking it to help with your migraines?

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Replies to "Tagging a few Mayo Clinic Connect members who may have some knowledge of or experience with..."

@lisalucier I researched CoQ10 back in the day but never took, if I recall. Never felt that supplements helped my cause. Sorry, cant help more.

@lisalucier
r I have been taking the following as a sort of migraine supplement cocktail. The premise is that many, many to factors can cause migraines and as you get older, high Cholesterol and Heart Health play an important role as having migraines especially with Aura put you at a higher risk for stroke and if you combine that with high Cholesterol your risk is even higher. The supplements I take support both heart health in combo with supplements that have been proven to help migraines (per Migraine World Summit). I take the following migraine and heart specific supplements:

AM
- Jarrow QH + PQQ (100mg Ubiquinol, PQQ 10mg
- Carlson’s 1capsule only Elite Omega 3 (2 capsules = 1,600mg)
- Nutricost Vitamin B2 Riboflavin 400mg
- Jarrow B12 + Folate (1000mcg, 400 mcg) every other day

PM
- Carlson’s 1capsule only Elite Omega 3 (2 capsules = 1,600mg)
- Vital Nutrients Magnesium + Malate (240mg 50/50%)

Using supplements is never a quick fix and it can’t take 3-6 months of consistency to see benefits. I do recommend addressing other underlying issues in parallel to actually get full benefits such as: high Cholesterol, exercise, sleep, inflammation, vision and hearing, and pore posture. It is vital you address your migraines via a Systems approach rather than just as a migraine focus as migraine is a symptom and not a root cause.

For extra context my Cholesterol numbers are okay (not terrible or great) and I have a calcium score of 0, yet my Cardiologist did a CT Angiogram of the Coronary with Plaque Analysis and discovered I had 25% stenosis of soft plaque (soft plaque moves and can make it to the brain). I take Nexlatol and Repatha to manage the Cholesterol and plaque. For me, the Cholesterol was a silent issue.

In summary, addressing both heart and migraine in combo has improved my migraine profile significantly. To maximize benefits I also in parallel address other issues listed above so I am treating my full migraine profile as a system.