@rlpostrp Chemotherapy is a common treatment for advanced prostate cancer that is polymetastatic (many metastases) or castrate-resistant (PSA still rises despite hormone therapy). Many forum members here, including @jeffmarc , have had chemotherapy as part of their cancer treatment, and I'm sure they'd be happy to share their experiences.

Chemotherapy is also part of the new "triplet therapy" pioneered partly at Mayo (along with several other research facilities). The old approach was to try one treatment at a time, and move onto the next when it failed. These days, the cutting edge for polymetastatic prostate cancer is to hit it with everything you've got right up front: ADT (like Orgovyx), an ARSI (like one of the -lutamides), *and* chemotherapy (Docetaxel), hoping for a knock-out punch. Some members have had chemo multiple times to keep their prostate cancer under control, and are doing great.