@riverbendab thank you so much for reaching out. I’ve heard about the newest anti-psychotic drug Cobenfy that does not have all the usual bad side effects of the other meds, but he said it is not as successful in severe cases, nor is Caplyta. The doctor started him on Lithium and Haldol (older drugs for bipolar1) over the weekend and after talking to my son last night I am seeing flashes of normality coming back, so fingers crossed. They worked for him a few years back so maybe will again.