Hello, I'm new to the group and have not read every comment/reply so possibly my contributions will be redundant. 3 years ago I was diagnosed with polyneuropathy (likely axonal damage) and Mal de Debarquement Syndrome (I think the French is the universal med term), the latter basically, as translated, the sensations one experiences when on land following a long sea voyage ... the earth is constantly moving beneath me not unlike being on a boat in varying swells (I'm not a sailor and very rarely on boats of any sort). The combination of the two conditions creates interesting challenges! The PN has been progressive with gradual loss of feeling initially, starting on left side, in the feet and gradually working up through the lower leg. In the past 6 months this loss of feeling in now in my fingers.
When the so-called specialists could not recommend any solutions other than pain remedies, which thankfully I don't experience, I began reviewing the available research on healing damaged nerves. There is considerable research with much more needed but I have found a basic consensus in several areas that to 'x' extent are discussed in this forum. Vitamins B1 B12 and B6 - B6 is known for its toxicity as has been mentioned in other comments - seems to be well established for not just protecting nerves but also for promoting healing of damaged nerves and best when working in combination. My basic protocol is a combination of B1 and B12 in relatively high doses with very limited doses of B6.
I do not want to mislead anyone so please know that I am highly dyslexic and can easily confuse what I am reading, not least technical details. So, rather than suggest a specific protocol, my aim is to provide some leads with the hope that others with greater skills can carry this forward. I specify 'research' with each search, sometimes using 'Pubmed research' but that's just my limited understanding of how to search these matters. Here is a recent (2025) paper you may find of interest:
The Combination of Neurotropic Vitamins B1, B6, and B12 Enhances Neural Cell Maturation and Connectivity Superior to Single B Vitamins
I've just learned that I cannot post links so the above was found within this search 'research pubmed dose axonal b12 b1 b6' which has other research papers you might find relevant.
Many thanks to each and all for your contributions which I am now gradually finding my way through 🙂